Orlistat 60 mg, marketed under the brand name Alli, is an over-the-counter medication designed to aid in weight loss for overweight adults. It works by inhibiting the absorption of dietary fats in the digestive system.

How Does Orlistat 60 mg Work?

Orlistat functions as a lipase inhibitor, blocking the action of enzymes that break down fats in the stomach and intestines. This results in approximately 25% of the fat consumed being excreted undigested, thereby reducing overall calorie intake and assisting in weight loss.

Recommended Dosage

• Dosage: Take one 60 mg capsule with each main meal containing fat.
• Frequency: Up to three times daily, not exceeding three capsules per day.
• Dietary Consideration: Use in conjunction with a reduced-calorie, low-fat diet.
• Timing: The capsule can be taken during the meal or up to one hour after eating.

Common Side Effects

Due to its fat-blocking mechanism, Orlistat may cause gastrointestinal side effects, especially when consuming high-fat meals. These include:

• Oily or fatty stools
• Increased bowel movements
• Urgent or difficult-to-control bowel movements
• Gas with oily spotting
• Stomach discomfort

These effects are typically temporary and may diminish over time with consistent use and adherence to a low-fat diet.

Serious Side Effects

Although rare, some individuals may experience more severe reactions, including:

• Severe stomach pain
• Severe pain in the lower back
• Blood in urine or painful urination
• Kidney problems (e.g., little or no urination, swelling in feet or ankles, feeling tired or short of breath)
• Liver problems (e.g., nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice)

If any of these symptoms occur, discontinue use and seek immediate medical attention.

Drug Interactions

Orlistat may interact with certain medications, including:

• Warfarin (blood thinner)
• Cyclosporine (immunosuppressant)
• Thyroid medications
• Antiretroviral drugs for HIV

It’s important to consult with a healthcare provider before starting Orlistat to discuss potential interactions and necessary adjustments to other medications.

Additional Information

• Multivitamin Supplementation: Since Orlistat can reduce the absorption of fat-soluble vitamins (A, D, E, and K), it’s recommended to take a daily multivitamin at bedtime, at least two hours before or after taking Orlistat.
• Effectiveness: Clinical studies have shown that individuals using Orlistat, along with a reduced-calorie, low-fat diet, can lose 5 to 10 pounds over six months, in addition to the weight lost through diet and exercise alone.
• Availability: Orlistat 60 mg is available over-the-counter under the brand name Alli. Prescription-strength Orlistat (120 mg) is available under the brand name Xenical.

1. What is Orlistat 60 mg used for?

Orlistat 60 mg is an over-the-counter medication used to aid in weight loss for overweight adults. It works by blocking the absorption of some of the fat in your diet, which helps reduce calorie intake.

2. How does Orlistat 60 mg work?

Orlistat works by inhibiting the action of enzymes (lipases) that break down fats in the digestive system. As a result, about 25% of the fat you consume is not absorbed and is excreted through your stool, leading to a reduction in calories.

3. How should I take Orlistat 60 mg?

• Take one 60 mg capsule with each main meal containing fat, up to three times daily.
• It can be taken during the meal or up to one hour after eating.
• For the best results, Orlistat should be used alongside a low-fat, reduced-calorie diet and regular physical activity.

4. What are the common side effects of Orlistat 60 mg?

Common side effects are mostly gastrointestinal and occur due to the undigested fat being excreted. These include:

• Oily or fatty stools
• Gas with oily spotting
• Diarrhea
• Stomach pain or discomfort
• Increased bowel movements

These side effects typically subside as your body adjusts to the medication.

5. What are the serious side effects of Orlistat 60 mg?

Serious side effects are rare but may include:

• Severe stomach pain
• Blood in stools or rectal bleeding
• Severe back pain
• Kidney problems (e.g., swelling, fatigue)
• Liver problems (e.g., dark urine, yellowing of skin or eyes)

If you experience any of these symptoms, stop using Orlistat and seek immediate medical attention.