Orlistat 120 mg (brand name Xenical) is a prescription medication used to aid in weight loss and weight maintenance in overweight or obese adults. It works by inhibiting the absorption of dietary fats in the gastrointestinal tract.

How Orlistat 120 mg Works

Orlistat functions as a lipase inhibitor, blocking the action of enzymes (lipases) that break down fats in the digestive system. As a result, approximately 25% of the fat consumed is not absorbed and is excreted undigested, leading to a reduction in calorie intake and assisting in weight loss.

Dosage and Administration

• Recommended Dose: 120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.
• Dietary Consideration: Orlistat should be used in conjunction with a reduced-calorie, low-fat diet. Meals should not exceed 30% of calories from fat to minimize gastrointestinal side effects.
• Missed Dose: If you miss a dose, skip it and take your next dose at the regular time. Do not take two doses at once to make up for a missed dose.

Common Side Effects

The most common side effects are gastrointestinal and occur due to the undigested fat being excreted:

• Oily or fatty stools
• Increased bowel movements
• Urgent need to have a bowel movement
• Gas with oily spotting
• Stomach discomfort

These side effects are typically temporary and may improve as your body adjusts to the medication.

Serious Side Effects

Serious side effects may include:

• Liver Damage: Symptoms may include nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, and jaundice.
• Kidney Problems: Symptoms may include decreased or no urine, swelling in the legs or feet, and fatigue.
• Gallbladder Problems: Symptoms may include pain in the upper stomach area, nausea, and vomiting.
• Severe Allergic Reactions: Symptoms may include rash, itching, swelling of the face or throat, and difficulty breathing.

If you experience any of these symptoms, seek immediate medical attention.

Drug Interactions

Orlistat may interact with certain medications, including:

• Cyclosporine: Take cyclosporine at least 3 hours before or after taking orlistat.
• Levothyroxine: Take levothyroxine at least 4 hours before or after taking orlistat.
• Fat-Soluble Vitamins: Orlistat can reduce the absorption of vitamins A, D, E, and K. Take a multivitamin containing these vitamins at least 2 hours before or after taking orlistat.

Always inform your healthcare provider of all medications and supplements you are taking before starting orlistat.

Additional Information

• Effectiveness: Clinical trials have shown that orlistat, when used alongside a reduced-calorie, low-fat diet, can lead to modest weight loss. Individuals may lose approximately 5 to 10 pounds more than with diet and exercise alone over the course of a year.
• Availability: Orlistat 120 mg is available by prescription under the brand name Xenical. The 60 mg dose is available over-the-counter under the brand name Alli.
• Storage: Store orlistat at room temperature (20°C to 25°C or 68°F to 77°F), away from heat, moisture, and light. Keep it out of reach of children.

1. What is Orlistat 120 mg used for?

Orlistat 120 mg is a prescription medication used to assist in weight loss and weight management for overweight or obese adults. It works by reducing the absorption of dietary fat, which helps to lower calorie intake.

2. How does Orlistat 120 mg work?

Orlistat works by inhibiting the action of enzymes (lipases) in the digestive system that break down fats. This results in approximately 25% of the fat you consume being excreted undigested, reducing your overall calorie intake and helping with weight loss.

3. How should I take Orlistat 120 mg?

• Take one 120 mg capsule with each of the three main meals of the day that contain fat.
• Orlistat should be taken during or up to 1 hour after a meal.
• It is recommended to use Orlistat along with a low-fat, reduced-calorie diet.
• Do not exceed three doses per day.

4. What are the common side effects of Orlistat 120 mg?

Common side effects are mainly gastrointestinal, due to the unabsorbed fat being excreted:

• Oily or fatty stools
• Increased bowel movements
• Urgent or difficult-to-control bowel movements
• Gas with oily spotting
• Stomach discomfort

These side effects often improve over time with consistent use and adherence to a low-fat diet.

5. What are the serious side effects of Orlistat 120 mg?

Although rare, serious side effects may include:

• Liver damage: Symptoms may include nausea, upper stomach pain, loss of appetite, dark urine, and jaundice.
• Kidney problems: Symptoms may include decreased or no urination, swelling in the legs or feet, or fatigue.
• Severe allergic reactions: Symptoms may include rash, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing.

If you experience any of these symptoms, seek immediate medical attention.