What is this medicine?
It is a combination diabetes medicine used to control Type 2 Diabetes.
It contains two drugs:
- Glimepiride (0.5 mg) – a sulfonylurea that helps the pancreas release more insulin.
- Metformin (1000 mg) – a biguanide that reduces sugar production in the liver and improves insulin use by the body.
How does it work?
1. Glimepiride
- Helps pancreas produce more insulin.
- Lowers blood sugar after meals.
2. Metformin
- Reduces liver sugar production.
- Slows sugar absorption from food.
- Improves insulin sensitivity so cells use sugar better.
Together, they help control blood sugar better than either medicine alone.
Why is it prescribed?
Doctors prescribe this combination for:
- Type 2 diabetes when metformin alone is not enough.
- Better blood sugar control throughout the day.
- Reducing the risk of long-term diabetes problems (kidney damage, nerve damage, heart issues).
How to take it
- Usually once or twice daily, with meals (especially because Metformin can cause stomach upset).
- Swallow the tablet whole with water.
- Take at the same time every day.
Do NOT skip meals—Glimepiride can cause low blood sugar if you take the tablet but do not eat.
Common side effects
From Glimepiride
- Low blood sugar (hypoglycemia)
Symptoms: sweating, shakiness, hunger, fast heartbeat, dizziness. - Weight gain (mild).
From Metformin
- Stomach upset
(gas, nausea, loose stools, stomach pain) - Taste changes
These usually improve after a few days or weeks.
Serious but rare side effects
- Very low blood sugar
- Lactic acidosis (rare but serious with Metformin)
Symptoms: fast breathing, severe weakness, muscle pain
→ Seek medical help immediately. - Allergic reaction (rash, swelling)
Who should avoid or use with caution
- People with severe kidney problems
- Severe liver disease
- Those who drink alcohol heavily
- Pregnant or breastfeeding women (only use if doctor approves)
- People with heart failure or dehydration
What to monitor
- Fasting blood sugar
- HbA1c (every 3 months)
- Kidney function
- Symptoms of low blood sugar
Important precautions
- Do not skip meals.
- Limit alcohol (increases risk of lactic acidosis).
- Inform the doctor before surgery, CT scan with contrast dye, or if you become sick (vomiting/diarrhea).
Robin Rickert –
Good medicine with noticeable improvement in my condition.
S Rhett Gist –
Helped me recover faster and improved my health.
Curtis Wigant –
Easy to take and gives good relief from the problem.
Christopher Doller –
Safe and effective medicine for daily use.
Andrew Krecklau –
Works well with no side effects for me.
Amy D Bailey –
Works well for long-term use if taken properly.
Pamels Dallmann –
Medicine works exactly as described.
Patricia Egge –
Helped maintain my health condition consistently.
Steve Terrell –
Affordable price and effective results, totally worth buying.
Anne Waldeck –
Helped me recover faster and improved my health.
Mark Blau –
Works gently and effectively without causing weakness.
Sharon Dorminy –
Works well when taken regularly as advised.
Jennifer Kettlewell –
Quality product, worth buying again.
Audrey Albring –
Good product and authentic medicine received.
Michael Ronga –
Good quality product and works as expected.