What is this medicine?
This is a combination tablet used to control Type 2 Diabetes.
It contains two medicines:
- Glimepiride (1 mg) – helps the pancreas release more insulin.
- Metformin (1000 mg) – reduces sugar made by the liver and helps the body use insulin better.
This combination helps keep blood sugar under control throughout the day.
How does it work?
1. Glimepiride
- Helps your pancreas release more insulin.
- Mainly lowers blood sugar after meals.
- Works quickly.
2. Metformin
- Reduces the liver’s sugar production.
- Helps your body respond better to insulin.
- Slows sugar absorption from food.
- Does not cause weight gain.
Together, they improve blood sugar control better than taking only one medicine.
Why do doctors prescribe it?
Doctors use this combination when:
- Metformin alone is not enough.
- You need stronger sugar control.
- Blood sugar is high in both fasting and post-meal readings.
- To reduce long-term diabetes complications (kidney, nerve, eye, and heart problems).
How to take it
- Usually once or twice daily, with meals.
- Most commonly taken with breakfast or dinner.
- Swallow the tablet whole with water.
Important:
Do NOT skip meals.
Glimepiride can cause low blood sugar if you take the tablet but do not eat.
Common side effects
From Glimepiride
- Low blood sugar (hypoglycemia)
Symptoms:- Sweating
- Shaking
- Hunger
- Dizziness
- Fast heartbeat
- Weakness
- Mild weight gain
From Metformin
- Stomach upset
(gas, nausea, loose stools, stomach pain) - Metallic taste
Most side effects improve after a few days.
Serious but rare side effects
- Very low blood sugar (more likely with 1 mg dose if meals skipped)
- Lactic acidosis (rare but serious with Metformin)
Symptoms: severe weakness, breathing fast, muscle pain, feeling very tired
→ Seek urgent medical care. - Allergic reaction (rash, swelling, difficulty breathing)
Who should avoid it
- Severe kidney problem patients
- Severe liver disease
- Heavy alcohol users
- Pregnant or breastfeeding women (only if doctor recommends)
- People with frequent vomiting/dehydration
- Those undergoing CT scan with dye (temporary stop of medicine may be needed)
What to monitor
- Fasting blood sugar
- Post-meal sugar
- HbA1c every 3 months
- Kidney function tests
- Signs of low blood sugar
Important precautions
- Eat meals on time.
- Avoid excessive alcohol.
- Drink enough water.
- Tell your doctor if you are unwell, vomiting, or dehydrated.
- Do not stop the medicine without your doctor’s advice.
Kurt Janots –
I am satisfied with this medicine and its results.
Michael Tarnowski –
Works well when taken regularly as advised.
Vicki Burnett –
Helped control my condition nicely and steadily.
Susan Mazzeo –
Works well for long-term use if taken properly.
Nadine Rapozo –
Helpful in managing my health issue properly.
Barry O Sullivan –
Genuine medicine, packaging was proper and delivery was on time.
Kristina Roberson –
Got positive results without any problem.
Sharon Dorminy –
Works well with no side effects for me.
cindy mcgilloway –
Works well when taken regularly as advised.
Chester Clark –
Relief was gradual but very effective in the long run.
Blake Kalmes –
I noticed improvement after few doses itself.
Philip Damuth –
Helped control my condition nicely and steadily.
Dale Loomis –
Medicine is effective and safe for regular use.
Gary Block –
Good alternative to more expensive brands with same effect.
Kelly Campbell –
Helpful in managing my health issue properly.
Adine Schuelke –
Helpful in managing my health issue properly.
Michael PERONA –
Relief was gradual but very effective in the long run.
Dennis W eimer –
Good results after few days of continuous use.
Rebecca armbruster –
Effective treatment and easy dosage to follow.
Julie Lewis –
Good medicine with noticeable improvement in my condition.
brett cornish –
Good results after few days of continuous use.
Michael Ronga –
Effective treatment and easy dosage to follow.